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Concern · Topic

Stress & Mood

Everyday tension, low mood, irritability, the sense of being "wound up but tired". The cluster of complaints that brings many Chinese adults to the family 中成药 drawer before they ever see a doctor.

Last reviewed: June 25, 2026

About this page

This page is a cultural reference, not a diagnostic tool. Health concerns listed here are tags that explain why certain formulas are discussed together — they do not map 1:1 to Western medical diagnoses.

Background

In TCM, the everyday language of "stress" maps onto several classical patterns: "liver qi stagnation" (irritability, sighing, a tight chest, premenstrual mood shifts), "heart-spleen deficiency" (overthinking, fatigue, poor sleep after a hard week), and "liver qi invading the spleen" (digestive upset that arrives with deadlines). The medicines on this page are not antidepressants, and they are not sedatives. They are formulas that Chinese households have traditionally associated with restoring a sense of ease. None of this is a substitute for clinical evaluation when low mood is severe or persistent.

Medicines traditionally associated with this concern

  • Formula · Guī Pí Wán

    Spleen-Restoring

    归脾丸

    A "heart-and-spleen tonifying" formula with a strong reputation in Chinese households for two connected complaints: difficulty falling asleep due to overthinking, and the kind of tiredness that comes from working or worrying too hard.

  • Formula · Jīn Guì Shèn Qì Wán

    Golden Cabinet Kidney Qi

    金匮肾气丸

    A "warm and tonify the kidney yang" formula from the Han dynasty, best understood as the six-ingredient Liuwei Dihuang Wan (Six Flavor Rehmanni) with cinnamon and aconite added back in to address the "yang" rather than the "yin" aspect.

  • Formula · Zhī Bǎi Dì Huáng Wán

    Anemarrhena and Phellodendron Rehmanni

    知柏地黄丸

    A "yin-tonic with heat-clearing" variation of Liuwei Dihuang Wan, best understood as the six-ingredient base formula with two "draining fire" herbs added to address pronounced "yin deficiency with fire" patterns.

  • Formula · Qǐ Jú Dì Huáng Wán

    Lycium and Chrysanthemum Rehmanni

    杞菊地黄丸

    A "liver-kidney yin tonic for the eyes" variation of Liuwei Dihuang Wan, best understood as the six-ingredient base with lycium fruit and chrysanthemum flower added to address dryness and fatigue of the eyes.

  • Formula · Lóng Dǎn Xiè Gān Wán

    Gentian Liver-Draining

    龙胆泻肝丸

    A strong "drain fire from the liver and gallbladder" formula, bitter, cold, and one of the most frequently discussed prescriptions for pronounced "liver fire" patterns in the head, eyes, and lower body.

  • Formula · Míng Mù Dì Huáng Wán

    Eye-Brightening Rehmanni

    明目地黄丸

    A "liver-kidney yin tonic for the eyes" formula with broader effect than Qi Ju Di Huang Wan, built on the six-ingredient base with additional eye-targeted herbs, used for chronic eye fatigue and early visual decline.

  • Formula · Niú Huáng Qīng Xīn Wán

    Calculus Bovis Heart-Clearing

    牛黄清心丸(局方)

    A high-end "clear the heart, open the orifices, calm the spirit" formula from the Song dynasty, one of the most expensive OTC preparations in Chinese pharmacies, traditionally given as a household "rescue" remedy.

  • Formula · Yuè Jū Wán

    Six Stagnations

    越鞠丸

    A "resolve the six stagnations" formula from the Yuan dynasty, qi, blood, phlegm, fire, dampness, and food, the classical TCM "regulate everything that gets stuck" formula.

  • Formula · Xiāo Yáo Piàn

    Free Wanderer Tablets

    逍遥片

    A flagship "tiao-he gan-pi" (harmonize liver and spleen) formula from the Song-dynasty "Formulary of the Bureau of Medicine" (1078), the most widely sold "liver-qi stagnation" formula in TCM.

  • Formula · Huáng Qí Jiàn Zhōng Wán

    Astragalus Construct Center Pills

    黄芪建中丸

    A "wen-zhong bu-xu, yi-qi jian-zhong" (warm the middle, tonify deficiency, augment qi, and build the center) formula from Zhang Zhongjing's "Essential Prescriptions of the Golden Cabinet" (c. 220 CE), the Astragalus-augmented form of Xiao Jian Zhong Tang.

  • Formula · Jiā Wèi Xiāo Yáo Wán

    Augmented Free Wanderer

    加味逍遥丸

    A "shu-gan qing-re, jian-pi yang-xue" (smooth the liver, clear heat, strengthen the spleen, nourish blood) formula from Li Chan's "Introduction to Medicine" (1575), the "cooled" form of the classical Xiao Yao San.

  • Formula · Dāng Guī Lóng Huì Wán

    Angelica Gentian Dragon

    当归龙荟丸

    A "qing-xie gan-dan shi-huo" (clear and drain excess fire from liver and gallbladder) formula from Liu Wansu's "Elucidations of Formulas" (1172), one of the most strongly purgative classical "liver-fire" formulas.

  • Formula · Ān Shén Bǔ Xīn Wán

    Calm-Spirit Heart-Tonifying

    安神补心丸

    A modern "yang-xin an-shen" (nourish the heart and calm the spirit) formula standardized in the 1977 Pharmacopoeia, the most widely sold TCM "insomnia + heart-flutter" formula in mainland China.

  • Formula · Rén Shēn Guī Pí Wán

    Ginseng Spleen-Returning

    人参归脾丸

    A "yi-qi bu-xue, jian-pi yang-xin" (augment qi, tonify blood, strengthen the spleen, nourish the heart) formula from Yan Yonghe's "Formulary to Aid the Living" (1253), the ginseng-substituted, stronger form of the classical Gui Pi Tang.

  • Formula · Bǎi Zǐ Yǎng Xīn Wán

    Biota Heart-Nourishing

    柏子养心丸

    A modern "yang-xin an-shen, zi-yin bu-shen" (nourish the heart and calm the spirit, enrich yin and tonify the kidney) formula standardized in the PRC Pharmacopoeia, the most widely sold "overworked heart-yin" formula in mainland China.

  • Formula · Zuǒ Guī Wán

    Left-Restoring

    左归丸

    A "pure tonification, no draining" (纯补无泻) kidney-yin formula from Zhang Jingyue's Ming-dynasty "Complete Works of Jingyue", the more potent, "no-draining" counterpart of the classic Liuwei Dihuang Wan.

  • Formula · Dà Huó Luò Wán

    Major Channel-Activating

    大活络丸

    A large, multi-action "qu-feng hua-tan huo-xue" (expel wind, transform phlegm, invigorate blood) formula from the Qing-dynasty "Standards of the Lantai", one of the most compound classical prescriptions in the TCM canon, with over forty ingredients.

  • Formula · Xiǎo Huó Luò Wán

    Minor Channel-Activating

    小活络丸

    A compact "qu-feng san-han hua-shi huo-xue" (expel wind, scatter cold, transform dampness, invigorate blood) formula from the Song-dynasty "Formulary of the Bureau of Medicine", the simpler, smaller-scale counterpart of Da Huo Luo Wan.

  • Formula · Sū Hé Xiāng Wán

    Liquidambar Opening

    苏合香丸

    A "wen-tong kai-qiao, pi-hui hua-zhuo" (warm and open the orifices, dispel turbidity) formula from the Song-dynasty "Formulary of the Bureau of Medicine", the most representative "warm-opening" prescription in the TCM canon, as opposed to the "cool-opening" An Gong Niu Huang Wan.

  • Formula · Dān Zhī Xiāo Yáo Wán

    Moutan-Gardenia Free Wanderer

    丹栀逍遥丸

    A "shu-gan jie-yu, qing-re liang-xue" (spread the liver, resolve constraint, clear heat, cool blood) formula from the Ming-dynasty "Essentials of Internal Medicine", the "heat-clearing" expansion of the classic Xiao Yao San.

  • Formula · Chuān Xiōng Chá Tiáo Wán

    Chuanxiong Tea-Adjusting

    川芎茶调丸

    A "shu-feng zhi-tong" (spread wind and stop pain) formula from the Song-dynasty "Formulary of the Bureau of Medicine", the most prescribed classical OTC formula for "wind-cold" headache, traditionally taken with green tea.